|
T2155 |
Thiazovivin
|
|
ROCK
|
|
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC. |
|
T2633 |
GSK429286A
|
RHO-15 |
ROCK
|
|
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM). |
|
T12747 |
ROCK2-IN-2
|
|
ROCK
|
|
|
|
TQ0187 |
SR-3677
|
|
ROCK
,
Autophagy
|
|
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). |
|
T1870 |
Y-27632
|
|
ROCK
,
Apoptosis
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. |
|
T14960 |
Chroman 1
|
|
ROCK
|
|
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM). |
|
T7885 |
Afuresertib hydrochloride
|
|
ROCK
,
Akt
,
PKC
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively) |
|
T7391 |
SAR407899
|
|
ROCK
,
Rho
|
|
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
|
T15798 |
LX7101
|
|
ROCK
,
LIM Kinase
,
PKA
|
|
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM). |
|
T7648 |
HA-100
|
|
Myosin
,
PKA
,
PKC
|
|
HA-100 is an inhibitor of protein kinase |
|
T12746 |
ROCK inhibitor-2
|
|
ROCK
|
|
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively). |
|
T7301 |
BDP5290
|
|
ROCK
|
|
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.) |
|
T1898 |
RKI-1447
|
RKI1447 |
ROCK
|
|
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. |
|
T3513 |
GSK180736A
|
GSK180736 |
ROCK
,
GRK
,
PKA
|
|
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM). |
|
T14989 |
CMPD101
|
|
ROCK
,
GRK
,
PKC
|
|
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I... |
|
T2482 |
AT13148
|
|
ROCK
,
SGK
,
Akt
,
PKA
,
S6 Kinase
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
|
T1911 |
Afuresertib
|
GSK2110183C,GSK2110183 |
ROCK
,
Akt
,
PKC
|
|
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. |
|
T4095 |
ZINC00881524
|
ROCK inhibitor |
ROCK
|
|
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor. |
|
T7764 |
CCG-222740
|
|
ROCK
,
Rho
,
Ras
|
|
CCG-222740 is an inhibitor of Rho/MRTF pathway |
|
T2011 |
RKI1313
|
RKI 1313,RKI-1313 |
ROCK
|
|
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion. |
|
T4488 |
GSK-25
|
GSK25 |
ROCK
,
S6 Kinase
,
mTOR
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
T13384L |
Y-33075 dihydrochloride
|
|
CaMK
,
ROCK
,
PKC
|
|
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM). |
|
T4276L |
Hydroxyfasudil
|
Hydroxy-Fasudil,HA-1100 |
ROCK
,
PKA
|
|
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively). |
|
TQ0110 |
ROCK-IN-2
|
TC-S 7001,Azaindole 1 |
ROCK
|
|
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2. |
|
T3518 |
GSK269962A
|
GSK269962B,GSK 269962,GSK269962A HCl |
ROCK
,
S6 Kinase
|
|
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
|
TQ0319 |
Ripasudil
|
K-115,Ripasudil hydrochloride dihydrate |
ROCK
|
|
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2). |
|
T23308 |
SAR407899 hydrochloride
|
|
ROCK
|
|
ATP-competitive ROCK inhibitor |
|
T6867 |
Belumosudil
|
KD025,Rezurock,ROCK inhibitor,SLx-2119 |
ROCK
|
|
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). |
|
T4276 |
Hydroxyfasudil Hydrochloride
|
Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride |
ROCK
|
|
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM). |
|
T1606 |
Fasudil
|
HA-1077,AT877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK. |
|
T1725 |
Y-27632 dihydrochloride
|
Y-27632 2HCl |
ROCK
,
Apoptosis
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. |
|
T3060 |
Fasudil hydrochloride
|
Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
HIV Protease
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively. |
|
T7552 |
H-1152
|
|
ROCK
|
|
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM). |
|
T7492 |
Ripasudil free base
|
K-115 (free base) |
ROCK
,
Antibacterial
|
|
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent. |
|
T10358 |
Netarsudil Dihydrochloride
|
AR-13324 Dihydrochloride |
ROCK
|
|
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. |
|
T35328 |
H-1152 dihydrochloride
|
H-1152 2HCl,H-1152 dihydrochloride |
ROCK
|
|
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ... |
|
T28608 |
ROCKII-IN-DI
|
|
|
|
ROCKII-IN-DI is a potent, competitive inhibitor of Rho-associated coiled-coil-containing protein kinase 2 (ROCKII). |
|
T10358L2 |
Netarsudil mesylate
|
AR-13324 (mesylate) |
Others
|
|
Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. |
|
T28469 |
PT-262
|
PT 262 |
|
|
PT-262 is a ROCK (Rho-associated coiled-coil forming protein kinase) inhibitor. It induces cytoskeleton remodeling and migration inhibition in lung carcinoma cells. |
|
T71120 |
AR-13503
|
|
|
|
AR-13503, is an metabolite of Netarsudil (AR-11324), is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. |
|
T26821 |
BIPM
|
|
|
|
BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits p... |
|
T35459 |
Glycyl H-1152 hydrochloride
|
|
|
|
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and prol... |
|
T71119 |
Netarsudil free base
|
|
|
|
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Hum... |
